868.2K XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Ellen V. Chiniara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 27,500 | 82,326 | - | 0 | Common Stock | |
| Ellen V. Chiniara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Ellen V. Chiniara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 31.00 per share. | 03 Mar 2025 | 408 | 80,085 | - | 31.0 | 12,650 | Common Stock |
| Ellen V. Chiniara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 30.33 per share. | 03 Mar 2025 | 1,833 | 80,493 | - | 30.3 | 55,590 | Common Stock |
| Jeremy G. Chadwick | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.33 per share. | 03 Mar 2025 | 1,131 | 68,052 | - | 30.3 | 34,300 | Common Stock |
| Jeremy G. Chadwick | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 25,000 | 69,183 | - | 0 | Common Stock | |
| Jeremy G. Chadwick | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.00 per share. | 03 Mar 2025 | 252 | 67,800 | - | 31.0 | 7,813 | Common Stock |
| Jeremy G. Chadwick | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 365,000 | 365,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.33 per share. | 03 Mar 2025 | 5,754 | 203,167 | - | 30.3 | 174,502 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 30,000 | 208,921 | - | 0 | Common Stock | |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 31.00 per share. | 03 Mar 2025 | 1,281 | 201,886 | - | 31.0 | 39,717 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.33 per share. | 03 Mar 2025 | 4,695 | 121,045 | - | 30.3 | 142,386 | Common Stock |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 30,000 | 125,740 | - | 0 | Common Stock | |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.00 per share. | 03 Mar 2025 | 1,045 | 120,000 | - | 31.0 | 32,400 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 10 Jan 2025 | 10,000 | 659,959 | - | 2.1 | 20,800 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2025 | 10,000 | 495,559 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 10 Jan 2025 | 10,000 | 178,921 | - | 2.1 | 20,800 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2025 | 10,000 | 94,899 | - | - | Stock Option (Right to Buy) | |
| Ellen V. Chiniara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 41.75 per share. | 06 Jan 2025 | 3,129 | 54,826 | - | 41.8 | 130,645 | Common Stock |
| Pamela Esposito | Director | Sale of securities on an exchange or to another person at price $ 49.00 per share. | 02 Dec 2024 | 2,500 | 0 | - | 49 | 122,500 | Common Stock |
| Pamela Esposito | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 2,500 | 29,127 | - | - | Stock Option (Right to Buy) | |
| Pamela Esposito | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.55 per share. | 02 Dec 2024 | 2,500 | 2,500 | - | 29.6 | 73,875 | Common Stock |
| Pamela Esposito | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2024 | 8,500 | 31,627 | - | - | Stock Option (Right to Buy) | |
| Pamela Esposito | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2024 | 5,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| Pamela Esposito | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.55 per share. | 17 Sep 2024 | 8,500 | 8,500 | - | 29.6 | 251,175 | Common Stock |
| Pamela Esposito | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.18 per share. | 17 Sep 2024 | 5,000 | 13,500 | - | 14.2 | 70,900 | Common Stock |
| Pamela Esposito | Director | Sale of securities on an exchange or to another person at price $ 47.75 per share. | 17 Sep 2024 | 6,350 | 7,150 | - | 47.7 | 303,185 | Common Stock |
| Pamela Esposito | Director | Sale of securities on an exchange or to another person at price $ 48.75 per share. | 17 Sep 2024 | 7,150 | 0 | - | 48.8 | 348,581 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 5,000 | 11,349 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Sale of securities on an exchange or to another person at price $ 49.10 per share. | 26 Aug 2024 | 5,000 | 0 | - | 49.1 | 245,509 | Common Stock |
| Jeffrey W. Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.34 per share. | 26 Aug 2024 | 5,000 | 5,000 | - | 10.3 | 51,700 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.10 per share. | 15 Jul 2024 | 9,864 | 95,470 | - | 46.1 | 454,696 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.59 per share. | 15 Jul 2024 | 13,281 | 105,604 | - | 45.6 | 605,522 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 15 Jul 2024 | 23,145 | 118,885 | - | 2.1 | 48,142 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.15 per share. | 15 Jul 2024 | 16,455 | 95,740 | - | 45.1 | 742,925 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 15 Jul 2024 | 16,455 | 112,195 | - | 2.1 | 34,226 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 23,145 | 22,883 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 16,455 | 46,028 | - | - | Stock Option (Right to Buy) | |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 35.57 per share. | 09 Jul 2024 | 24,449 | 4,523,951 | - | 35.6 | 869,651 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 39.26 per share. | 09 Jul 2024 | 20,238 | 723,246 | - | 39.3 | 794,544 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 38.48 per share. | 09 Jul 2024 | 38,606 | 743,484 | - | 38.5 | 1,485,559 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 37.41 per share. | 09 Jul 2024 | 8,769 | 782,090 | - | 37.4 | 328,048 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 36.40 per share. | 09 Jul 2024 | 6,030 | 790,859 | - | 36.4 | 219,492 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 35.57 per share. | 09 Jul 2024 | 5,133 | 796,889 | - | 35.6 | 182,581 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 39.26 per share. | 09 Jul 2024 | 96,386 | 4,173,216 | - | 39.3 | 3,784,114 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 38.48 per share. | 09 Jul 2024 | 183,868 | 4,269,602 | - | 38.5 | 7,075,241 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 37.41 per share. | 09 Jul 2024 | 41,763 | 4,453,470 | - | 37.4 | 1,562,354 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 36.40 per share. | 09 Jul 2024 | 28,718 | 4,495,233 | - | 36.4 | 1,045,335 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 18,773 | 288,456 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.33 per share. | 01 Jul 2024 | 18,773 | 649,959 | - | 5.3 | 100,060 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 27 Jun 2024 | 25,000 | 168,554 | - | 2.1 | 52,000 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jun 2024 | 25,000 | 104,899 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 18 Jun 2024 | 14,413 | 631,186 | - | 2.1 | 29,979 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jun 2024 | 14,413 | 505,559 | - | - | Stock Option (Right to Buy) | |
| John M. Maraganore | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Booth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Elena H. Ridloff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Victor Sandor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Pamela Esposito | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Gorjan Hrustanovic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Leigh Morgan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 34.98 per share. | 12 Jun 2024 | 1,770 | 802,022 | - | 35.0 | 61,915 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 34.98 per share. | 12 Jun 2024 | 8,430 | 4,548,400 | - | 35.0 | 294,881 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 36.02 per share. | 12 Jun 2024 | 420 | 803,792 | - | 36.0 | 15,128 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 35.35 per share. | 12 Jun 2024 | 2,485 | 804,212 | - | 35.4 | 87,845 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 36.02 per share. | 12 Jun 2024 | 1,997 | 4,556,830 | - | 36.0 | 71,932 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 35.35 per share. | 12 Jun 2024 | 11,838 | 4,558,827 | - | 35.3 | 418,473 | Common Stock |
| Joanna Horobin | Director | 07 Jun 2024 | 8,500 | 8,500 | - | 2.1 | 17,680 | Common Stock | |
| Joanna Horobin | Director | 07 Jun 2024 | 2,187 | 6,313 | - | 32.6 | 71,395 | Common Stock | |
| Joanna Horobin | Director | 07 Jun 2024 | 8,500 | 33,195 | - | - | Stock Option (Right to Buy) | ||
| Joanna Horobin | Director | 07 Jun 2024 | 6,313 | 0 | - | 33.1 | 209,005 | Common Stock | |
| Jeremy G. Chadwick | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.99 per share. | 23 May 2024 | 2,575 | 44,183 | - | 35.0 | 90,105 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 39.73 per share. | 14 Mar 2024 | 34,473 | 4,641,602 | - | 39.7 | 1,369,612 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 40.62 per share. | 14 Mar 2024 | 49,591 | 4,572,258 | - | 40.6 | 2,014,386 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 39.31 per share. | 14 Mar 2024 | 8,126 | 4,621,849 | - | 39.3 | 319,433 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 41.51 per share. | 14 Mar 2024 | 154 | 819,151 | - | 41.5 | 6,393 | Common stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 40.66 per share. | 14 Mar 2024 | 2,233 | 819,305 | - | 40.7 | 90,794 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 39.73 per share. | 14 Mar 2024 | 7,292 | 821,538 | - | 39.7 | 289,711 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 41.51 per share. | 14 Mar 2024 | 781 | 4,629,975 | - | 41.5 | 32,419 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 41.23 per share. | 14 Mar 2024 | 1,593 | 4,570,665 | - | 41.2 | 65,679 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 39.31 per share. | 14 Mar 2024 | 1,714 | 817,437 | - | 39.3 | 67,377 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 41.23 per share. | 14 Mar 2024 | 329 | 806,697 | - | 41.2 | 13,565 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 40.66 per share. | 14 Mar 2024 | 10,846 | 4,630,756 | - | 40.7 | 440,998 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 40.62 per share. | 14 Mar 2024 | 10,411 | 807,026 | - | 40.6 | 422,895 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.77 per share. | 11 Mar 2024 | 37,180 | 4,930,934 | - | 42.8 | 1,590,189 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.84 per share. | 11 Mar 2024 | 1,386 | 828,830 | - | 42.8 | 59,376 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.19 per share. | 11 Mar 2024 | 22,779 | 830,216 | - | 42.2 | 961,046 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.84 per share. | 11 Mar 2024 | 6,686 | 4,676,075 | - | 42.8 | 286,428 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.19 per share. | 11 Mar 2024 | 108,404 | 4,682,761 | - | 42.2 | 4,573,565 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.52 per share. | 11 Mar 2024 | 1,819 | 852,995 | - | 42.5 | 77,344 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 41.94 per share. | 11 Mar 2024 | 26,452 | 854,814 | - | 41.9 | 1,109,397 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.52 per share. | 11 Mar 2024 | 8,581 | 4,791,165 | - | 42.5 | 364,864 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 41.94 per share. | 11 Mar 2024 | 126,066 | 4,799,746 | - | 41.9 | 5,287,208 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 43.42 per share. | 11 Mar 2024 | 1,045 | 881,266 | - | 43.4 | 45,374 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 42.77 per share. | 11 Mar 2024 | 7,837 | 882,311 | - | 42.8 | 335,188 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 43.42 per share. | 11 Mar 2024 | 5,122 | 4,925,812 | - | 43.4 | 222,397 | Common Stock |
| Ellen Chiniara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 130,531 | 130,531 | - | - | Stock Option (Right to Buy) | |
| Ellen Chiniara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 21,755 | 55,960 | - | 0 | Common Stock | |
| Jeremy G. Chadwick | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 80,548 | 80,548 | - | - | Stock Option (Right to Buy) | |
| Jeremy G. Chadwick | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 13,425 | 46,758 | - | 0 | Common Stock | |
| Nello Mainolfi | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 530,000 | 530,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 43.25 per share. | 01 Mar 2024 | 255 | 142,351 | - | 43.3 | 11,030 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 01 Mar 2024 | 1,301 | 142,606 | - | 42.4 | 55,153 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 41.41 per share. | 01 Mar 2024 | 2,378 | 143,907 | - | 41.4 | 98,481 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 31,250 | 146,285 | - | 0 | Common Stock | |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 187,500 | 187,500 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 01 Mar 2024 | 1,106 | 95,956 | - | 42.4 | 46,886 | Common Stock |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 24,375 | 99,084 | - | 0 | Common Stock | |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 43.25 per share. | 01 Mar 2024 | 216 | 95,740 | - | 43.3 | 9,343 | Common Stock |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 146,250 | 146,250 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 41.41 per share. | 01 Mar 2024 | 2,022 | 97,062 | - | 41.4 | 83,738 | Common Stock |
| Gollob Jared | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 27 Feb 2024 | 400 | 74,709 | - | 45 | 18,000 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 400 | 62,483 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 27 Feb 2024 | 400 | 75,109 | - | 2.1 | 832 | Common Stock |
| W. Albers Jeffrey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 4,385 | 16,349 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Albers W. | Director | Sale of securities on an exchange or to another person at price $ 39.07 per share. | 20 Feb 2024 | 615 | 0 | - | 39.1 | 24,031 | Common Stock |
| W. Albers Jeffrey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.34 per share. | 20 Feb 2024 | 4,385 | 4,385 | - | 10.3 | 45,341 | Common Stock |
| W. Albers Jeffrey | Director | Sale of securities on an exchange or to another person at price $ 39.05 per share. | 20 Feb 2024 | 4,385 | 0 | - | 39.0 | 171,227 | Common Stock |
| Jeffrey Albers W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.34 per share. | 20 Feb 2024 | 615 | 615 | - | 10.3 | 6,359 | Common Stock |
| W. Jeffrey Albers | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2024 | 615 | 20,734 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2024 | 46,137 | 62,883 | - | - | Stock Option (Right to Buy) | |
| Gollob Jared | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 09 Feb 2024 | 46,137 | 120,846 | - | 2.1 | 95,965 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 36.09 per share. | 09 Feb 2024 | 7,398 | 74,709 | - | 36.1 | 267,013 | Common Stock |
| Gollob Jared | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.39 per share. | 09 Feb 2024 | 38,739 | 82,107 | - | 35.4 | 1,371,058 | Common Stock |
| W. Albers Jeffrey | Director | Sale of securities on an exchange or to another person at price $ 30.05 per share. | 23 Jan 2024 | 10,000 | 0 | - | 30.0 | 300,470 | Common Stock |
| Albers W. Jeffrey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.34 per share. | 23 Jan 2024 | 10,000 | 10,000 | - | 10.3 | 103,400 | Common Stock |
| Albers Jeffrey W. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2024 | 10,000 | 21,349 | - | - | Stock Option (Right to Buy) | |
| Ellen Chiniara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 22.58 per share. | 04 Jan 2024 | 3,295 | 34,205 | - | 22.6 | 74,416 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 9,000 | 519,972 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 02 Jan 2024 | 9,000 | 615,570 | - | 2.1 | 18,720 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2023 | 12,000 | 2,368 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Aug 2023 | 12,000 | 586,570 | - | 2.1 | 24,960 | Common Stock |
| John M. Maraganore | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Joanna Horobin | Director | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | ||
| Bruce Booth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Elena H. Ridloff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Victor Sandor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Pamela Esposito | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Gorjan Hrustanovic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Leigh Morgan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 02 Jun 2023 | 10,000 | 115,035 | - | 2.1 | 20,800 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2023 | 10,000 | 129,899 | - | - | Stock Option (Right to Buy) | |
| Jeremy G. Chadwick | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 33,333 | 33,333 | - | 0 | Common Stock | |
| Jeremy G. Chadwick | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 450,000 | 450,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 23,750 | 105,938 | - | 0 | Common Stock | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.88 per share. | 01 Mar 2023 | 1,056 | 104,882 | - | 30.9 | 32,607 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 142,500 | 142,500 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 31.40 per share. | 01 Mar 2023 | 314 | 104,568 | - | 31.4 | 9,859 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.40 per share. | 01 Mar 2023 | 297 | 74,709 | - | 31.4 | 9,325 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.88 per share. | 01 Mar 2023 | 1,001 | 75,006 | - | 30.9 | 30,908 | Common Stock |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 18,750 | 76,007 | - | 0 | Common Stock | |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 112,500 | 112,500 | - | - | Stock Option (Right to Buy) | |
| Elaine Caughey | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 30.88 per share. | 01 Mar 2023 | 550 | 19,150 | - | 30.9 | 16,983 | Common Stock |
| Elaine Caughey | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 10,557 | 19,700 | - | 0 | Common Stock | |
| Elaine Caughey | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 63,338 | 63,338 | - | - | Stock Option (Right to Buy) | |
| Elaine Caughey | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 31.40 per share. | 01 Mar 2023 | 164 | 18,986 | - | 31.4 | 5,149 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.29 per share. | 11 Jan 2023 | 77,128 | 4,968,114 | - | 30.3 | 2,336,207 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.29 per share. | 11 Jan 2023 | 21,592 | 890,148 | - | 30.3 | 654,022 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 11 Jan 2023 | 6,071 | 911,740 | - | 30.0 | 181,887 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 11 Jan 2023 | 21,683 | 5,045,242 | - | 30.0 | 649,623 | Common Stock |
| Ellen Chiniara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 225,000 | 225,000 | - | - | Stock Option (Right to Buy) | |
| Ellen Chiniara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 37,500 | 37,500 | - | 0 | Common Stock | |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.28 per share. | 14 Dec 2022 | 112,819 | 5,252,744 | - | 30.3 | 3,416,159 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 14 Dec 2022 | 717 | 917,811 | - | 30 | 21,510 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 14 Dec 2022 | 2,561 | 5,066,925 | - | 30 | 76,830 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 34.02 per share. | 14 Dec 2022 | 3,733 | 918,528 | - | 34.0 | 126,997 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 33.34 per share. | 14 Dec 2022 | 3,919 | 922,261 | - | 33.3 | 130,659 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 32.33 per share. | 14 Dec 2022 | 15,324 | 926,180 | - | 32.3 | 495,425 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 31.44 per share. | 14 Dec 2022 | 28,329 | 941,504 | - | 31.4 | 890,664 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.28 per share. | 14 Dec 2022 | 31,584 | 969,833 | - | 30.3 | 956,364 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 34.02 per share. | 14 Dec 2022 | 13,335 | 5,069,486 | - | 34.0 | 453,657 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 33.34 per share. | 14 Dec 2022 | 13,997 | 5,082,821 | - | 33.3 | 466,660 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 32.33 per share. | 14 Dec 2022 | 54,737 | 5,096,818 | - | 32.3 | 1,769,647 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 31.44 per share. | 14 Dec 2022 | 101,189 | 5,151,555 | - | 31.4 | 3,181,382 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2022 | 10,000 | 18,725 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Dec 2022 | 10,000 | 573,700 | - | 2.1 | 20,800 | Common Stock |
| Victor Sandor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Nov 2022 | 24,000 | 24,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 02 Nov 2022 | 21,085 | 1,001,417 | - | 30 | 632,550 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 02 Nov 2022 | 75,312 | 5,365,563 | - | 30 | 2,259,360 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.02 per share. | 02 Nov 2022 | 27,038 | 1,022,502 | - | 30.0 | 811,681 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.02 per share. | 02 Nov 2022 | 96,581 | 5,440,875 | - | 30.0 | 2,899,362 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 28 Oct 2022 | 19,915 | 1,092,771 | - | 30 | 597,450 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 31.08 per share. | 28 Oct 2022 | 1,044 | 1,049,540 | - | 31.1 | 32,448 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 31.08 per share. | 28 Oct 2022 | 3,727 | 5,537,456 | - | 31.1 | 115,835 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.57 per share. | 28 Oct 2022 | 15,804 | 1,050,584 | - | 30.6 | 483,128 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.57 per share. | 28 Oct 2022 | 56,455 | 5,541,183 | - | 30.6 | 1,725,829 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.23 per share. | 28 Oct 2022 | 26,383 | 1,066,388 | - | 30.2 | 797,558 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.23 per share. | 28 Oct 2022 | 94,239 | 5,597,638 | - | 30.2 | 2,848,845 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 28 Oct 2022 | 71,135 | 5,691,877 | - | 30 | 2,134,050 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 21 Oct 2022 | 10,000 | 81,279 | - | 2.1 | 20,800 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2022 | 10,000 | 139,899 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2022 | 32,056 | 14,368 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 17 Oct 2022 | 27,676 | 561,931 | - | 2.1 | 57,566 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 17 Oct 2022 | 32,056 | 534,255 | - | 2.1 | 66,676 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2022 | 27,676 | 546,604 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 17 Oct 2022 | 10,000 | 71,279 | - | 2.1 | 20,800 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2022 | 10,000 | 149,899 | - | - | Stock Option (Right to Buy) | |
| Leigh Morgan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jul 2022 | 24,000 | 24,000 | - | - | Stock Option (Right to Buy) | |
| Elena H. Ridloff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jun 2022 | 9,000 | 9,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Joanna Horobin | Director | 15 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | ||
| Bruce Booth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Elena H. Ridloff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Pamela Esposito | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Donald W. Nicholson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Gorjan Hrustanovic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2022 | 9,792 | 109,020 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2022 | 10,208 | 29,799 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 04 May 2022 | 9,792 | 57,257 | - | 2.1 | 20,367 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.31 per share. | 04 May 2022 | 10,208 | 47,465 | - | 1.3 | 13,372 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 03 May 2022 | 20,000 | 502,199 | - | 2.1 | 41,600 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2022 | 20,000 | 46,424 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2022 | 20,000 | 159,899 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 03 May 2022 | 20,000 | 60,814 | - | 2.1 | 41,600 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 275,100 | 275,100 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 13,300 | 40,814 | - | 0 | Common Stock | |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 75,800 | 75,800 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 12,600 | 37,257 | - | 0 | Common Stock | |
| Elaine Caughey | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 7,000 | 7,000 | - | 0 | Common Stock | |
| Elaine Caughey | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 41,000 | 41,000 | - | - | Stock Option (Right to Buy) | |
| John M. Maraganore | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 24,000 | 24,000 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2022 | 10,000 | 66,424 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 14 Jan 2022 | 10,000 | 482,199 | - | 2.1 | 20,800 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 14 Jan 2022 | 10,000 | 27,514 | - | 2.1 | 20,800 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2022 | 10,000 | 179,899 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 53.27 per share. | 12 Jan 2022 | 1,422 | 17,514 | - | 53.3 | 75,747 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 52.13 per share. | 12 Jan 2022 | 7,151 | 18,936 | - | 52.1 | 372,788 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 51.21 per share. | 12 Jan 2022 | 6,427 | 26,087 | - | 51.2 | 329,149 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 12 Jan 2022 | 15,000 | 32,514 | - | 2.1 | 31,200 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2022 | 15,000 | 36,974 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.27 per share. | 10 Jan 2022 | 1,623 | 472,440 | - | 53.3 | 86,457 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 52.02 per share. | 10 Jan 2022 | 4,022 | 474,063 | - | 52.0 | 209,210 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.31 per share. | 10 Jan 2022 | 2,726 | 478,085 | - | 51.3 | 139,877 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 10 Jan 2022 | 8,612 | 480,811 | - | 2.1 | 17,913 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.05 per share. | 10 Jan 2022 | 347 | 472,199 | - | 55.1 | 19,103 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.42 per share. | 10 Jan 2022 | 6,644 | 472,546 | - | 54.4 | 361,582 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.68 per share. | 10 Jan 2022 | 9,932 | 479,190 | - | 53.7 | 533,109 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 10 Jan 2022 | 16,923 | 489,122 | - | 2.1 | 35,200 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.99 per share. | 10 Jan 2022 | 106 | 472,199 | - | 55.0 | 5,829 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.40 per share. | 10 Jan 2022 | 4,201 | 472,305 | - | 54.4 | 228,545 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.35 per share. | 10 Jan 2022 | 10,673 | 476,506 | - | 53.3 | 569,379 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 10 Jan 2022 | 22,465 | 494,664 | - | 2.1 | 46,727 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 52.46 per share. | 10 Jan 2022 | 7,485 | 487,179 | - | 52.5 | 392,644 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2022 | 8,612 | 574,280 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2022 | 16,923 | 582,892 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2022 | 22,465 | 599,815 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.97 per share. | 10 Jan 2022 | 241 | 472,199 | - | 54.0 | 13,007 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 16 Dec 2021 | 8,000 | 472,199 | - | 2.1 | 16,640 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2021 | 8,000 | 76,424 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2021 | 10,000 | 199,899 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 23 Nov 2021 | 10,000 | 17,256 | - | 2.1 | 20,800 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 64.34 per share. | 01 Nov 2021 | 1,202 | 24,657 | - | 64.3 | 77,333 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 63.50 per share. | 01 Nov 2021 | 5,280 | 25,859 | - | 63.5 | 335,287 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 62.89 per share. | 01 Nov 2021 | 8,514 | 31,139 | - | 62.9 | 535,442 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 01 Nov 2021 | 14,996 | 39,653 | - | 2.1 | 31,192 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 63.17 per share. | 01 Nov 2021 | 4,065 | 24,657 | - | 63.2 | 256,799 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 62.34 per share. | 01 Nov 2021 | 15,911 | 28,722 | - | 62.3 | 991,946 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 61.50 per share. | 01 Nov 2021 | 15,134 | 44,633 | - | 61.5 | 930,709 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.40 per share. | 01 Nov 2021 | 7,387 | 59,767 | - | 60.4 | 446,142 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.31 per share. | 01 Nov 2021 | 20,000 | 62,547 | - | 1.3 | 26,200 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 01 Nov 2021 | 4,607 | 67,154 | - | 2.1 | 9,583 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2021 | 14,996 | 118,812 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2021 | 4,607 | 133,808 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2021 | 20,000 | 40,007 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.56 per share. | 08 Oct 2021 | 21,236 | 484,507 | - | 55.6 | 1,179,868 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Oct 2021 | 6,456 | 28,725 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Oct 2021 | 41,544 | 35,181 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.50 per share. | 08 Oct 2021 | 744 | 464,199 | - | 54.5 | 40,546 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.58 per share. | 08 Oct 2021 | 5,712 | 464,943 | - | 53.6 | 306,044 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Oct 2021 | 6,456 | 470,655 | - | 2.1 | 13,428 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.87 per share. | 08 Oct 2021 | 271 | 464,199 | - | 61.9 | 16,767 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.32 per share. | 08 Oct 2021 | 670 | 464,470 | - | 60.3 | 40,412 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.28 per share. | 08 Oct 2021 | 7,920 | 465,140 | - | 59.3 | 469,463 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 57.29 per share. | 08 Oct 2021 | 2,078 | 473,060 | - | 57.3 | 119,046 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.82 per share. | 08 Oct 2021 | 9,369 | 475,138 | - | 56.8 | 532,391 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Oct 2021 | 41,544 | 505,743 | - | 2.1 | 86,412 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.05 per share. | 03 Sep 2021 | 8,500 | 8,756 | - | 60.1 | 510,436 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2021 | 10,000 | 209,899 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.50 per share. | 03 Sep 2021 | 1,500 | 7,256 | - | 60.5 | 90,744 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 03 Sep 2021 | 10,000 | 17,256 | - | 2.1 | 20,800 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 60.12 per share. | 27 Aug 2021 | 33,779 | 0 | - | 60.1 | 2,030,864 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Aug 2021 | 33,779 | 263,340 | - | - | Stock Option (Right to Buy) | |
| Richard Chesworth | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.00 per share. | 27 Aug 2021 | 33,779 | 33,779 | - | 20 | 675,580 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2021 | 12,000 | 84,424 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 19 Aug 2021 | 12,000 | 464,199 | - | 2.1 | 24,960 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.09 per share. | 17 Aug 2021 | 288 | 0 | - | 52.1 | 15,002 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 51.68 per share. | 17 Aug 2021 | 2,928 | 288 | - | 51.7 | 151,325 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.37 per share. | 17 Aug 2021 | 41,975 | 3,216 | - | 50.4 | 2,114,243 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.90 per share. | 17 Aug 2021 | 8,809 | 45,191 | - | 49.9 | 439,612 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.00 per share. | 17 Aug 2021 | 54,000 | 54,000 | - | 20 | 1,080,000 | Common Stock |
| Richard Chesworth | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2021 | 54,000 | 297,119 | - | - | Stock Option (Right to Buy) | |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 61.00 per share. | 11 Aug 2021 | 242,133 | 0 | - | 61 | 14,770,113 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.07 per share. | 03 Aug 2021 | 5,669 | 452,199 | - | 60.1 | 340,533 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2021 | 1,037 | 76,725 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2021 | 5,669 | 77,762 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.03 per share. | 03 Aug 2021 | 1,037 | 452,199 | - | 60.0 | 62,253 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 03 Aug 2021 | 1,037 | 453,236 | - | 2.1 | 2,157 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 03 Aug 2021 | 5,669 | 457,868 | - | 2.1 | 11,792 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jul 2021 | 680 | 113,166 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jul 2021 | 23,456 | 83,431 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jul 2021 | 6,279 | 106,887 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.21 per share. | 29 Jul 2021 | 300 | 452,199 | - | 62.2 | 18,662 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.28 per share. | 29 Jul 2021 | 1,524 | 452,499 | - | 61.3 | 93,387 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.21 per share. | 29 Jul 2021 | 21,632 | 454,023 | - | 60.2 | 1,302,355 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 29 Jul 2021 | 23,456 | 475,655 | - | 2.1 | 48,788 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.07 per share. | 29 Jul 2021 | 6,279 | 452,199 | - | 60.1 | 377,167 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 29 Jul 2021 | 6,279 | 458,478 | - | 2.1 | 13,060 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 29 Jul 2021 | 680 | 452,199 | - | 60 | 40,800 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 29 Jul 2021 | 680 | 452,879 | - | 2.1 | 1,414 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 26 Jul 2021 | 9,015 | 461,214 | - | 2.1 | 18,751 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jul 2021 | 3,864 | 113,846 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jul 2021 | 9,015 | 117,710 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.15 per share. | 26 Jul 2021 | 3,864 | 452,199 | - | 60.1 | 232,410 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 26 Jul 2021 | 3,864 | 456,063 | - | 2.1 | 8,037 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.15 per share. | 26 Jul 2021 | 9,015 | 452,199 | - | 60.1 | 542,237 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Jul 2021 | 48,000 | 500,199 | - | 2.1 | 99,840 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2021 | 48,000 | 126,725 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.64 per share. | 08 Jul 2021 | 595 | 452,199 | - | 51.6 | 30,724 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.96 per share. | 08 Jul 2021 | 6,372 | 452,794 | - | 51.0 | 324,717 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.71 per share. | 08 Jul 2021 | 23,803 | 459,166 | - | 49.7 | 1,183,333 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.15 per share. | 08 Jul 2021 | 17,230 | 482,969 | - | 49.2 | 846,855 | Common Stock |
| Elaine Caughey | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2021 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | |
| Joanna Horobin | Director | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | ||
| Steven E. Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | |
| Bruce Booth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | |
| Elena H. Ridloff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | |
| Pamela Esposito | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | |
| Donald W. Nicholson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | |
| Gorjan Hrustanovic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,063 | 20,063 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2021 | 40,000 | 96,424 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 14 Jun 2021 | 40,000 | 452,199 | - | 2.1 | 83,200 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.46 per share. | 10 Jun 2021 | 6,912 | 418,193 | - | 51.5 | 355,724 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 10 Jun 2021 | 23,009 | 435,208 | - | 2.1 | 47,859 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.63 per share. | 10 Jun 2021 | 10,103 | 425,105 | - | 50.6 | 511,537 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 52.53 per share. | 10 Jun 2021 | 5,994 | 412,199 | - | 52.5 | 314,845 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2021 | 23,009 | 174,725 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 07 Jun 2021 | 12,724 | 424,923 | - | 2.1 | 26,466 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2021 | 5,752 | 197,734 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2021 | 270 | 203,486 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2021 | 12,724 | 203,756 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.02 per share. | 07 Jun 2021 | 5,752 | 412,199 | - | 50.0 | 287,721 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 07 Jun 2021 | 5,752 | 417,951 | - | 2.1 | 11,964 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 07 Jun 2021 | 270 | 412,199 | - | 50 | 13,500 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 07 Jun 2021 | 270 | 412,469 | - | 2.1 | 562 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.14 per share. | 07 Jun 2021 | 12,724 | 412,199 | - | 50.1 | 638,040 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 46.66 per share. | 03 Jun 2021 | 5,506 | 11,494 | - | 46.7 | 256,905 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2021 | 10,000 | 219,899 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 47.13 per share. | 03 Jun 2021 | 4,494 | 7,256 | - | 47.1 | 211,790 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 03 Jun 2021 | 10,000 | 17,256 | - | 2.1 | 20,800 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2021 | 15,000 | 136,424 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 19 May 2021 | 15,000 | 412,199 | - | 2.1 | 31,200 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.05 per share. | 12 May 2021 | 8,245 | 397,199 | - | 50.1 | 412,677 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2021 | 8,245 | 216,480 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 12 May 2021 | 8,245 | 405,444 | - | 2.1 | 17,150 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.26 per share. | 22 Apr 2021 | 10,959 | 397,199 | - | 40.3 | 441,182 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2021 | 2,768 | 224,725 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2021 | 680 | 227,493 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2021 | 10,959 | 228,173 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.18 per share. | 22 Apr 2021 | 2,768 | 397,199 | - | 40.2 | 111,229 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 22 Apr 2021 | 2,768 | 399,967 | - | 2.1 | 5,757 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.01 per share. | 22 Apr 2021 | 680 | 397,199 | - | 40.0 | 27,208 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 22 Apr 2021 | 680 | 397,879 | - | 2.1 | 1,414 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 22 Apr 2021 | 10,959 | 408,158 | - | 2.1 | 22,795 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.29 per share. | 15 Apr 2021 | 4,940 | 391,199 | - | 40.3 | 199,039 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2021 | 6,000 | 151,424 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2021 | 653 | 239,132 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2021 | 4,940 | 239,785 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 15 Apr 2021 | 6,000 | 397,199 | - | 2.1 | 12,480 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 15 Apr 2021 | 653 | 391,199 | - | 40.0 | 26,121 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 15 Apr 2021 | 653 | 391,852 | - | 2.1 | 1,358 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 15 Apr 2021 | 4,940 | 396,139 | - | 2.1 | 10,275 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 15,000 | 157,424 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 13 Apr 2021 | 15,000 | 391,199 | - | 2.1 | 31,200 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 7,000 | 229,899 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 13 Apr 2021 | 7,000 | 7,000 | - | 2.1 | 14,560 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 33.32 per share. | 08 Apr 2021 | 4,905 | 376,199 | - | 33.3 | 163,414 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2021 | 15,267 | 244,725 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2021 | 22,794 | 259,992 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2021 | 9,939 | 282,786 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.29 per share. | 08 Apr 2021 | 10,362 | 381,104 | - | 32.3 | 334,566 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Apr 2021 | 15,267 | 391,466 | - | 2.1 | 31,755 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 34.19 per share. | 08 Apr 2021 | 3,742 | 376,199 | - | 34.2 | 127,923 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 33.58 per share. | 08 Apr 2021 | 19,052 | 379,941 | - | 33.6 | 639,827 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Apr 2021 | 22,794 | 398,993 | - | 2.1 | 47,412 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.62 per share. | 08 Apr 2021 | 2,323 | 376,199 | - | 35.6 | 82,748 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 34.81 per share. | 08 Apr 2021 | 7,616 | 378,522 | - | 34.8 | 265,084 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Apr 2021 | 9,939 | 386,138 | - | 2.1 | 20,673 | Common Stock |
| Bruce Booth | Director | Sale of securities on an exchange or to another person at price $ 56.50 per share. | 12 Mar 2021 | 229,350 | 0 | - | 56.5 | 12,958,275 | Common Stock |
| Elena H. Ridloff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2021 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 11 Mar 2021 | 1,805 | 1,805 | - | 2.1 | 3,754 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2021 | 8,195 | 234,061 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2021 | 1,805 | 242,256 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.17 per share. | 11 Mar 2021 | 8,195 | 0 | - | 60.2 | 493,096 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 11 Mar 2021 | 8,195 | 8,195 | - | 2.1 | 17,046 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.07 per share. | 11 Mar 2021 | 1,805 | 0 | - | 60.1 | 108,432 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.31 per share. | 11 Mar 2021 | 2,200 | 49,747 | - | 1.3 | 2,882 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2021 | 7,800 | 60,007 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2021 | 2,200 | 67,807 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.17 per share. | 11 Mar 2021 | 10,305 | 42,547 | - | 60.2 | 620,052 | Common Stock |
| Jared Gollob | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.31 per share. | 11 Mar 2021 | 7,800 | 52,852 | - | 1.3 | 10,218 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.05 per share. | 11 Mar 2021 | 4,695 | 45,052 | - | 60.1 | 281,939 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 50.46 per share. | 08 Mar 2021 | 7,699 | 2,301 | - | 50.5 | 388,482 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2021 | 10,000 | 244,061 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 52.00 per share. | 08 Mar 2021 | 1 | 0 | - | 52 | 52 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 51.28 per share. | 08 Mar 2021 | 2,300 | 1 | - | 51.3 | 117,936 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 08 Mar 2021 | 10,000 | 10,000 | - | 2.1 | 20,800 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 44.12 per share. | 03 Mar 2021 | 6,881 | 13,119 | - | 44.1 | 303,611 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2021 | 20,000 | 254,061 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.75 per share. | 03 Mar 2021 | 1,100 | 0 | - | 45.7 | 50,323 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.07 per share. | 03 Mar 2021 | 12,019 | 1,100 | - | 45.1 | 541,700 | Common Stock |
| Bruce Jacobs | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 03 Mar 2021 | 20,000 | 20,000 | - | 2.1 | 41,600 | Common Stock |
| Nello Mainolfi | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 375,000 | 375,000 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 140,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Richard Chesworth | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.91 per share. | 22 Feb 2021 | 8,675 | 47,547 | - | 50.9 | 441,671 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 52.63 per share. | 22 Feb 2021 | 9,104 | 75,507 | - | 52.6 | 479,130 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 49.65 per share. | 22 Feb 2021 | 19,285 | 56,222 | - | 49.7 | 957,554 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.09 per share. | 17 Feb 2021 | 8,887 | 84,611 | - | 55.1 | 489,559 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 58.39 per share. | 17 Feb 2021 | 7,550 | 99,997 | - | 58.4 | 440,836 | Common Stock |
| Jared Gollob | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.94 per share. | 17 Feb 2021 | 6,499 | 93,498 | - | 55.9 | 363,540 | Common Stock |
| Pamela Esposito | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Sep 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | |
| Steven E. Hall | Director | 25 Aug 2020 | 2,192,249 | 2,192,249 | - | - | Common Stock | ||
| Steven E. Hall | Director | 25 Aug 2020 | 985,220 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Steven E. Hall | Director | 25 Aug 2020 | 2,511,198 | 0 | - | - | Series A Convertible Preferred Stock | ||
| Bruce Booth | Director | 25 Aug 2020 | 1,112,686 | 1,112,686 | - | - | Common Stock | ||
| Bruce Booth | Director | 25 Aug 2020 | 1,774,624 | 0 | - | - | Series C Convertible Preferred Stock | ||
| Bruce Booth | Director | 25 Aug 2020 | 7,000,000 | 0 | - | - | Series A Convertible Preferred Stock | ||
| Bruce Booth | Director | 25 Aug 2020 | 3,000,000 | 0 | - | - | Series Seed Convertible Preferred Stock | ||
| Bruce Booth | Director | 25 Aug 2020 | 7,196,584 | 7,948,982 | - | - | Common Stock | ||
| Bruce Booth | Director | 25 Aug 2020 | 1,477,832 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Jeffrey W. Albers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | |
| Joanna Horobin | Director | 20 Aug 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | ||
| Steven E. Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | |
| Bruce Booth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | |
| Donald W. Nicholson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | |
| Nello Mainolfi | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 125,399 | 125,399 | - | - | Stock Option (Right to Buy) | |
| Bruce Jacobs | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 32,904 | 32,904 | - | - | Stock Option (Right to Buy) | |
| Jared Gollob | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 48,942 | 48,942 | - | - | Stock Option (Right to Buy) | |
| Richard Chesworth | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 351,119 | 351,119 | - | - | Stock Option (Right to Buy) | |
| Andrew Hedin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) | |
| Gorjan Hrustanovic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Aug 2020 | 40,127 | 40,127 | - | - | Stock Option (Right to Buy) |